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    K48-linked Tetra-Ubiquitin

    產品編號 規格 價格 貨期
    UBC-484 25ug ¥1050 現貨
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     K48-linked Tetra-Ubiquitin  
     
    Cat. # UBC-484
    Product specification: 25 μg /vial
    General lnformation
    Poly-ubiquitylation of target proteins through linkage at K48, is now the most thoroughly studied of the various chain linkages, and was once considered the hallmark of this post- translational modification. It is now clear that many, if not all, poly-Ub chain topologies likely play distinct and important roles in regulating cellular processes. Nevertheless, K48 linkage remains a critical pathway for the cells to maintain homeostasis through proteolytic degradation, and as such remains very intriguing for the study of DUBs that play a role in the degradation, as well as the proteasome itself. These di-ubiquitin chains are generated from the enzymatic linkage (E2-25K) of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for a lysine at position 48, limiting the chain length.
     
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